Biological response modifier

Open studies are marked with a purple background, closed studies have a grey background, studies to be opened have a white background
13001
Phase I clinical trial of recombinant viscumin ( rViscumin,rMistletoe lectin,rML) administered twice weekly by the subcutaneous route in patients with solid tumors after failure of standard therapy
16002
Phase I clinical trial of recombinant mistletoe lectin (rML,rViscumin) administered twice weekly by the intravenous route in patients with solid tumors after failure of standard chemotherapy
13992
A phase I, open label multiple dose, safety and pharmacokinetic study of intravenously administered humanized anti-VEGF monoclonal antibody (HuMV833) to patients with relapsed or refractory solid tumors.
06971
A Phase III Study of PSC-833 in Combination with Vincristine, Doxorubicin and Dexamethasone (PSC-833/VAD) versus VAD Alone in Patients with Relapsing and Refractory Multiple Myeloma
06964
Phase II study of the efficacy of rH Inteleukin-2 in patients with slowly progressing acute myelogenous leukemia (AML) and with limited bone marrow blastosis after autologous stem cell transplantation or chemotherapy.
08962
A phase III study of Marimastat in patients with small cell lung cancer following a response to first line chemotherapy.
06952
Induction with All-Trans Retinoic Acid in combination with Idarubicin followed by intensive consolidation followed by bone marrow transplantation or a randomized maintenance treatment depending upon the amount of minimal residual disease in collaboration with GIMEMA-AIEOP Cooperative Groups)
24921
Phase II study of Interferon alpha and 5-fluorouracil in locally advanced or recurrent or metastatic squamous cell carcinoma of the head and neck
30924
Randomized phase II / III study of high dose intensity M-VAC chemotherapy + G-CSF versus classic M-VAC in advanced urothelial tract tumors
06923
Randomized phase III study testing the effect of bone marrow transplantation or conventional chemotherapy with or without alpha Interferon for aggressive myeloma
06911
Pilot study for the evaluation of rhGM-CSF before induction chemotherapy in hairy cell leukemia
06915
A randomized phase III trial of all transRetinoic Acid followed by conventional chemotherapy versus conventional chemotherapy alone in acute promyelocytic leukemia.
06913
Pilot Study of VAD (vincristine, doxorubicin, dexamethasone) combined with cyclosporin in patients with progressive multiple myeloma.
06903
A randomized phase III multicenter trial comparing LD-ARA-C alone versus LD-ARA-C + GM-CSF versus LD-ARA-C + recombinant interleukin-3 for patients with myelodysplastic syndromes and a high risk of developing acute leukemia
06902
A pilot multicenter study of recombinant human interleukin-3 (IL-3) plus LD-ARA-C in patients with myelodysplastic syndromes and a risk of developing acute leukemia
06892
A randomized phase III study on the value of GM-CSF administration as an adjunct to intensive remission induction chemotherapy in elderly patients with acute myelogenous leukemia
08883
Phase III trial on the evaluation of gamma Interferon for intensification/ maintenance of complete or near complete response in small cell lung cancer
06885
A randomized phase I - II dose-finding study of human GM-CSF in patients with MDS at relatively low risk of developing acute leukemia
06886
Randomized phase II study with GM-CSF and low-dose ARA-C in patients with "high risk" myelodysplastic syndromes
06872
Phase II study of the effect of tumor necrosis factor (TNF-alpha) in refractory or relapsed acute non-lymphoblastic leukemia
62043
Phase II study of GW786034 in patients with relapsed or refractory soft tissue sarcoma
18961
Adjuvant ganglioside GM2-KLH/QS-21 Vaccination Post-operative adjuvant ganglioside GM2-KLH/QS-21 vaccination treatment vs observation after resection of primary cutaneous melanoma (AJCC stage II, T3-T4N0M0), a 2-arm multicenter randomized phase III trial
06975
A phase II Multicenter study of Amifostine in patients with myelodysplastic dyndromes at relatively low risk of developing acute leukemia
06891
A randomized phase I/II multicenter study of recombinant human interleukin-3 (IL-3) in patients with myelodysplastic syndromes at relatively low risk of developing acute leukemia.
06023
Randomized phase II trial with infliximab (Remicade (R)) in patients with myelodysplastic syndrome and a relatively low risk of developing acute leukemia.
40071
Effectiveness of first line treatment with lapatinib and ECF/X in histologically proven adenocarcinoma of the stomach or the esophagogastric junction, metastatic or not amenable to curative surgery according to HER2 and EGFR status: a randomized phase II trial.
06031
Gemtuzumab ozogamicin (GO) monotherapy versus standard supportive care for previously untreated AML in elderly patients who are not eligible for intensive chemotherapy : a randomized phase II/III trial (AML-19) of the EORTC-LG and GIMEMA-ALWP.
11001
10B-uptake in different tumours using the boron compounds BSH and BPA.
08061
Phase II study of sunitinib (SU11248) in patients with small cell lung cancer who are either chemo-naïve (extensive disease) or have a "sensitive" relapse.
40051
Randomized phase II trial evaluating the feasibility and tolerance of the combination of FOLFOX with cetuximab and the combination of FOLFOX with cetuximab and bevacizumab as perioperative treatment in patients with resectable liver metastases from colorectal cancer (BOS).
58941
Cyclosporine A after autologous bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission. A phase I/II trial
40052
Adjuvant treatment of fully resected stage III colon cancer with folfox-4 versus folfox-4 plus cetuximab (PETACC-8)

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